APLIKASI GELATIN KULIT KAMBING BLIGON SEBAGAI BAHAN DASAR DALAM FORMULA TERHADAP SIFAT-SIFAT CANGKANG KAPSUL OBAT
ABSTRACT: Shell of commercial
capsule (CC) is generally made of gelatin from skin or bone of cows and pigs,
while the capsule shell made from goat skin is not widely publicized. This study
aims to determine the properties shell of hard capsules of gelatin from Bligon
goat skin. The gelatin from male Bligon goat skin (GBGS), glycerol, MgCO3,
tapioca and sago starch were used as main materials, and than shell of CC
number zero was used as a control. The Simplex Lattice Design method was used
to prepare formula of shell. A number 10 g of GBGS + 9 g of glycerol + 22 mg of
MgCO3 + 5.5 mg of tapioca starch + 72.1 mg of sago starch were used as formula
of capsule shell. An uniformity weight ofshell (average, deviation and
coefficient of variation) and than disintegration time (coefficient of
variation) were used as parameter of this study. The data of this study were analyzed
by descriptively with shell of CC as control. The results showed that the
average of weight and disintegration time of shell from GBGS higher than CC.
The solubility (dissolution) of active ingredient (paracetamol) on shell from
GBGS has maximum percentage of 95.85% with dissolution in the thirty minute,
and therefore has been declared the eligibility criteria of dissolution by the
British Pharmacopeae 2007.
Penulis: Muhammad Irfan Said,
Suharjono Triatmojo
Kode Jurnal: jppeternakandd140323
