EFEK GEL EKSTRAK HERBA PEGAGAN (Centella asiatica L. Urban) DENGAN GELLING AGENT HIDROKSIPROPIL METHYLCELLULOSE TERHADAP PENYEMBUHAN LUKA BAKAR PADA KULIT PUNGGUNG KELINCI
Abstract: Pegagan (Centella
asiatica L. Urban) contain saponin asiaticoside, which is a structural protein.
The compound plays a role in the wound healing process by the formation of
collagen. This research was conducted to determine the effect of wound healing
of burns on New Zealand male rabbits using gel extract of Pegagan (Centella
asiatica L. Urban) herbs using hydroxypropyl methylcellulose (HPMC) as gelling
agent. This research was an experimental with the same subject design, using ve
male New Zealand rabbits to test the wound healing of burns, and the backs of
each rabbit were divided into six treatment i.e : positive control
(Bioplasenton), negative control (no treatment), control HPMC base (no
extract), and three formula with herbal extracts of Centella asiatica with a
concentration of gelling agent HPMC 8%, 9%, and 10% respectively. Gel was
applied to the back of rabbits with the use ± 0.3 grams once daily until the
wound diameter equal to zero or until healed. The data was analyzed by one way
anava with a 95% confidence level. The result showed that of the gelling agent
HPMC concentration effect on the increased the viscosity, and decreased the
spreadability and the burn wound healing time is a longer. Gel herb pegagan
extract (Centella asiatica L. Urban) with a gelling agent HPMC concentration of
8% (17,60±1,14 days) most effectively heal burns compared to the concentration
of 9% (19,40 ±1,14 days) and concentration 10% (20,40±1,14 days).
Penulis: Tanti Azizah Sujono,
Ullya Nur Wahyu Hidayah, T.N. Saifullah Sulaiman
Kode Jurnal: jpkedokterandd140561
