EKSPRESI ANTI-HELICOBACTER PYLORI PADA GASTRITIS KRONIS, LESI PRAKANKER, DAN KARSINOMA GASTER
Abstract: Prevalence of
Helicobacter pylori infection in Indonesia was 36-46%. In Jakarta and Surabaya,
the prevalence were 85,7%-93,9%. Helicobacter pylori infection play role in
pathogenesis of pectic ulcers, chronic gastritis, carcinoma of gaster and
gastric lymphoma. Epidemiologic study showed 80% of carcinoma of gaster related
with H pylori infection.This study analyzed expression of anti-Helicobacter
pylori in chronic gastritis, precancer lesion , and carcinoma of gaster. This
study was a observational descriptive study with case control design. Thirty
(30) samples from paraffin bloc that were diagnosed with chronic gastritis,
precancer lesion, and carcinoma of gaster at Dokter Kariadi hospital in 2013
was stained by hematoxylin eosin, giemsa and immunohistochemistry of
anti-helicobacter pylori. Data was analyzed by descriptive analysis. Thirty
(30) samples were diagnosed as gastritis chronis 13 (43,3% ), pra cancer
lesion(36.6%), and carcinoma(20.1%). Chronic gastritis can be occurred at all
age and no distinct difference on sex, while gastric carcinoma predominant in
male older than 40 years. Expresion of Helicobacter pylori on chronic gastritis
was 84.6%, precancer lesion was 54.5%, and gastric carcinoma was 83.3%. The
Giemsa stain gave 23.3% false positive and 20% false negative. Helicobacter
pylori expression can be showed in chronic gastritis, precancer lesion, and
gastric carcinoma.
Penulis: Lina Damayanti,
Bambang Hendro Putranto, Udadi Sadhana
Kode Jurnal: jpkedokterandd150447
