HUBUNGAN IMUNOEKSPRESI HUMAN TELOMERASE RESERVE TRANSCRIPTASE (HTERT) DAN VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) DENGAN GRADASI HISTOPATOLOGI MENINGIOMA
ABSTRACT: Meningioma is a
tumor composed of cells of neoplastic meningothelial (arachnoidal) cells that a
rise from the arachnoid membrane and the layer of the arachnoid villi
associated with intradural venous sinuses and surrounding tissue. Meningiomas
tumors is one of the central nervous system (CNS) the most commonly found (the
second sequence) and generally grow slowly. Approximately 60-95% activity of
telomerase (hTERT ) found on meningiomas and can induces VEGF . The aim of this
study is to determine the role of hTERT and VEGF in meningiomas grading .
Methods: This study is conducted using analytic observasional cross
sectional method and had been analyzed with
unpaired categorical analysis of the 60 cases of meningioma (46 cases
grade I, 7 cases grade II, and7 cases grade III). The sample were obtained the
archive of Anatomical Pathology Department, Faculty of Medicine, Padjadjaran
University/Dr. Hasan Sadikin Hospital
Result: The result of this study showed: 44 cases (96%) grade I
meningiomas showed positive hTERT imunoexpression weak to strong, 2 cases(4%)
non-reactive and VEGF imunoexpression showed strong positive 12 cases (26%), 24
cases(52%) were moderate positive and 10 cases (22%) weak positive. 7 cases
(100%) grade II showed a strong positive hTERT imunoexpression and 5 cases
(71%) showed a strong positive VEGF imunoexpression, 2 cases (29%) were
moderate positive. 6 cases (86%) grade III showed strong positive hTERT imunoexpression,
1 case (14%) were moderate positive and 7 cases(100%) showed a strong positive
VEGF imunoexpression. Statistical analysis revealed imunoexpression VEGF showed
stronger positivity with p- value = 0.02 (< 0.05) compared to the hTERT
imunoexpression with p-value = 0.73
(> 0.05).
Conclusion: More affecting angiogenesis gradations meningiomas, seen by
the presence of VEGF higher imunoexpression on higher gradations. hTERT
Imunoexpression cannot determine of the meningiomas histopathological grading.
Penulis: Betty Marlina,
Anglita Yantisetiasti, Abdul Hadi Hassan, Bethy S Hernowo
Kode Jurnal: jpkedokterandd140581
