KORELASI EKSPRESI VEGF DAN DENSITAS MIKROVESEL DENGAN RESPONS RADIOTERAPI ADENOKARSINOMA SERVIKS
ABSTRACT: Most of cervical
carcinoma patients, including cervical adenocarcinoma comes at an advanced
stage and thus radiotherapy is one of the modality treatment. The success of
radiotherapy depends on several prognostic factors such as the performance,
staging, histopathology of tumor, presence of organ dysfunction and cellular
biology marker such as VEGF. Activation singaling pathway Vascular Endothelial
Growth Factor (VEGF) can induce radioresistance on cervical adenocarcinoma.
Activation angiogenesis mediated by VEGF can be counted from microvessel
density (MVD). Counting MVD use imunohistochemical CD34 on endothelial cells
form capiller of blood vessel in peritumoral. The aim of this study was to determine
correlation between immunohistochemistry VEGF dan MVD with neoadjuvant
radiotherapy response cervical adenocarcinoma.
Methods: This study was an observational study, cross-sectional and
correlational analysis. Samples was collected by total sampling with amount 32
samples block parafin from Departement Anatomical Pathology General Hospital
Dr. Hasan Sadikin Bandung and treated with complete neoadjuvant radiotherapy
from Januari 2007 until December 2013. Immunohistochemical examination of VEGF
and CD34 for counting MVD was done on all sample block parafin.
Result: There was a strong correlation between microvessel density (MVD)
with neoadjuvant radiotherapy response in cervical adenocarcinoma (p = 0.000).
In this study MVD above 30 correlate with poor neoadjuvant radiotherapy
response in cervical adenocarcinoma.
Conclusion: Examination MVD recommended for cervical adenocarcinoma
patient before radiation treatment.
Penulis: Fennisia Wibisono, Sri
Suryanti, Bethy S Hernowo
Kode Jurnal: jpkedokterandd140592
