MEKANISME RESISTENSI ISONIAZID & MUTASI GEN KATG SER315THR (G944C) MYCOBACTERIUM TUBERCULOSIS SEBAGAI PENYEBAB TERSERINGRESISTENSI ISONIAZID
ABSTRACT: Resistance to
anti-tuberculosis drugs mainly occurs due to a mutation in the genes of Mycobacterium
tuberculosis. Mutations can be induced by inadequate therapeutic levels of
drug, mainly due to non-compliance for taking the drug. Therefore, the use of
anti-tuberculosis drugs inappropriately and irregularly can lead to mutation in
the gene encoding the target of anti-tuberculosis drugs. Inadequate therapeutic
levels of drug due to non-compliance of patients taking isoniazid was the most
frequent causing mutations in KatG
(Ser315Thr) gene. Therefore, concluded that this mutation was the commonest cause
of INH resistance and could be a potential genetic marker for predicting
MDR-TB.
Penulis: Mara Imam Taufiq
Siregar
Kode Jurnal: jpkedokterandd150496
