CYTOTOXIC AND ANTI-VIRAL ACTIVITY OF Acacia catechu ON HUMAN PERIPHERAL BLOOD MONONUCLEAR CELLS
Abstract: As per the
literature, medicinal plants showed enormous candidates who is responsible or
showing anti-microbial, anti-cancer, anti-diabetic, anti-inflammatory agents
etc. Most of the research group focused only on those primary and secondary
metabolites extracted from different medicinal plants and showed its
antimicrobial (anti-viral) activity against dreadful pathogens. The objective
of our current study is to evaluate the cytotoxic and anti-viral effect of
aqueous leaves extract of Acacia catechu against new castle disease Virus (NDV)
on human peripheral blood mononuclear cells (PBMC). For these studies, variable
doses of aqueous leaves extract of Acacia catechu (0.5–30mg/mL, 50µL; dissolved
in phosphate buffered saline, PBS) and examined its proliferation assay
containing NDV and also determined CD14 monocyte surface marker in presence or
absence of NDV using flow cytometry. The results showed that aqueous leaves
extract of Acacia catechu inhibited NDV proliferation and also decline in CD14
monocyte surface marker with or without NDV at higher doses. Overall, aqueous
extract of Acacia catechu at higher doses showed cytotoxic as well as antiviral
effect and might be used for this purpose.
Author: Amit Gupta, Sushama R.
Chaphalkar
Journal Code: jpfarmasigg160030
Artikel Terkait :
Jp Farmasi gg 2016
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