DETERMINATION OF SIBUTRAMINE ADULTERATED IN HERBAL SLIMMING PRODUCTS USING TLC DENSITOMETRIC METHOD
Abstract: Determination of
sibutramine adulterated in herbal slimming product using thin layer
chromatography (TLC) densitometric method with TLC silica gel 60 F254 aluminium
plate as stationary phase and mixture of toluen-diethylamine (10:0.3) as mobile
phase has been developed. The calibration curve in the concentration range of
0.50 to 5.00 µg/spot showed good linier relationship (r2 = 0.9986). The limit
of detection and quantitation (LOD and LOQ) were 217.5 ng and 724.9 ng/spot,
respectively. The method gave satisfactory specificity, linierity, precision
and accuracy validation criteria and was applied for determination of
sibutramine in herbal slimming products obtained from several drugstrores in
Depok City, West Java, Indonesia. Results of the determination showed that six
of seven samples analyzed were detected containing sibutramine HCl with the
concentration of 2.45 - 26.24 mg in a single dosage of slimming herbal products
Author: Hayun, Baitha P
Maggadani, Nurul Amalina
Journal Code: jpfarmasigg160022
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