FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF GRANISETRON HYDROCHLORIDE USING PLANTAGO OVATE AS NATURAL SUPERDISINTEGRANTS
Abstract: The main objective
of the study was to develop orodispersible tablets of Granisetron
hydrochloride, a selective 5-HT3 receptor antagonist (an antivomiting agent)
for improving patient compliance, especially those of paediatric &
geriatric categories with difficulties in swallowing. In the wet granulation
method orodispersible (ORD) tablets were prepared using natural super
disintegrants plantago ovate.The
prepared batches of tablets were evaluated for weight variation, hardness,
friability, wetting time, in vitro dispersion time, drug content and in vitro
dissolution studies. The tablet formulation batch F4 was considered as the
overall best formulation (with an in vitro drug release study of 99.11%).Short
term stability studies (at 40±2ºC/75±5% RH) on the best formulation indicated
that there no significant changes in drug content. From the Fourier Transform
Infrared (FTIR) spectroscopy study indicated that there are no drug excipient
interactions.
Key words: Granisetron hydrochloride, Orodispersible
tablets, FTIR spectroscopy, in vitro drug release
Author: Chinmaya Keshari
Sahoo, Nalini Kanta Sahoo, Madushima Sahu, V.Alagarsamy ., Alok Kumar Moharana,
Deepak Kumar Sarangi, Kokkula Satyanarayana
Journal Code: jpfarmasigg160017

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