FORMULATION DEVELOPMENT AND CHARACTERIZATION OF TEA TREE OIL LOADED ETHOSOMES
Abstract: To prepare ethosomes
containing tea tree oil by hot homogenization method and to evaluate its
physical characters and in-vitro release pattern. the preformulation studies were carried out
by standard procedure. The morphology of globule was studied by optical
microscopy. The globule size and zeta potential was determined by Zetasizer,
respectively and in-vitro study was done by diffusion method and the drug content
was analyzed by HPTLC method. The release kinetics was also studied by fitting
into few mathematical models. All the
formulations were showed spherical and unilamellar shape with globule size of
931 to 975 nm, the zeta potential in the range of – 40 to -52 mV and entrapment
efficiency was 57 to 65 %. Finally the invitro release studies showed the drug
release from the ethosomal vesicles was burst release at initial time followed
by sustained release over throughout the study. From the above consideration of
evaluation studies, the tea tree oil loaded ethosomal formulation F5 shows best
globule size, zeta potential and entrapment efficiency. The sustained action
was confirmed by invitro release studies. All the formulations are followed
zero order drug release and diffusion type of mechanism of drug releases with
Fickian model. Ethosome loaded tea tree oil could be the best choice for
topical application.
Author: Vijayan Venugopal
Journal Code: jpfarmasigg160023
Artikel Terkait :
Jp Farmasi gg 2016
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