PENGARUH PEMBERIAN EKSTRAK METANOL-AIR DAUN Macaranga tanarius L. TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA TIKUS YANG TERBEBANI GLUKOSA
Abstract: This research aim to
find out the effect of M. tanarius leaf methanol-water extract (MTME) whether
it can lowering blood glucose levels. This research was experimental study with
one way-complete-random design using 25 male rats which divided into five
groups. The rats in group I were given CMC 1% (negative control). The group II
rats were given 0.45 g/kg BW dose of Glibenclamide (positive control). In group
III, IV and V, the rats were given 0.43; 1.28; 3.84 g/kg BW doses of MTME
orally. The hypoglycemic effect of MTME was tested by using the Oral Glucose
Tolerance Test (OGTT) method. The blood-glucose contents were measured at the
0, 15, 30, 60, 90, 180, and 240 after the OGTT and treatment. The AUC were
statistically analyzed using one way ANOVA and Scheffe test with 95 %
convidence level. The result show that MTME at dose 0.43; 1.28; and 3.84 g/kg
BW was effective in improving oral glucose tolerance.
Penulis: Martina Tri
Handayani, Phebe Hendra
Kode Jurnal: jpfarmasidd130305
