PENGARUH PENGGUNAAN PARASETAMOL SELAMA KEHAMILAN TERHADAP PREEKLAMPSIA
Abstract: Preeclampsia is one
of the causes of maternal death. The important factor of preeclampsia's
pathophysiology is reduction of PGI2 as vasodilator. It causes vasoconstriction
which influences the formation of desidua. Paracetamol is the most widely used
antipyretic in the world. Mechanism of action of paracetamol may lead to
preeclampsia. The aim of this research was to determine the relation between
paracetamol used during pregnancy and preeclampsia in RS X Yogyakarta. The
research was an analytical epidemiology with case control study design. Data
were obtained from medical record and interview. Sample size was 137 maternal
patients in October-December 2013 and 72 maternal have been followed up. Data
were analyzed using descriptive statistics, Chi-square tests, and logistic
regression. Preeclampsia patients were taking paracetamol during pregnancy
(71.8%), aged 30-40 years (84.6%), and had preeclampsia family history (28.2)
than non preeclampsia patient. Chi-square test showed the relation between
paracetamol used (p=0.010, OR= 3.46 (95%CI= 1.30 – 9.22), dose a day (p=0.010,
OR= 3.18 (95%CI= 1.12 – 9.06), duration of paracetamol used (p=0.005, OR= 7.75
(95%CI= 1.60 – 37.53), and used within first trimester (p=0.878, OR= 0.91
(95%CI= 0.26 – 3.12) to preeclampsia. Logistic regression analyses showed no
correlation between variables to preeclampsia. Women who used paracetamol
during pregnancy had an increased risk of preeclampsia.
Penulis: Dita Maria Virginia
Kode Jurnal: jpfarmasidd130310
