PENGGUNAAN OBAT SITOSTATIKA PADA ANAK-ANAK YANG MELAKUKAN KEMOTERAPI DI RSUP Dr. SARDJITO YOGYAKARTA TAHUN 2010
Abstract: Approximately 11.000
new child cancer cases per annum. An appropriate cytostatic drug regimen can
worse renal function. Aims of this research to determine the use of cytotoxic
in children chemotherapy based on GFR according Schwartz and CB formulas in
RSUP Dr. Sardjito Yogyakarta 2010 period. Cytotoxic drugs include antibiotic
and non antibiotic cytotoxics. An observational descriptive evaluative study
with retrospective design was done. Inclusion criteria were patient 0 – 12
years with creatinine serum data and exclusion criteria were acute or chronic
kidney failure with creatinine serum >5 mg/dL. The data taken were patient's
age, height, weight, and creatinine serum. Adjustment doses was evaluated based
on 2 GFR <60 mL/min/1.73 m for cytotoxic drugs. Dose adjustment was
evaluated according to DIH and BSA guidelines. Using 171 patient's datas with
160 cases of antibiotics prescription and 704 cases of non antibiotics
prescription. 1,8%; 5,6% cases of antibiotics prescription and 1,0%; 3,6% cases
of non antibiotics prescription required adjusment doses according to the
Schwartz and CB formulas. Unappropriate doses were found for doxorubicine and
bleomycine as cytotoxic antibiotics usage and etoposide, L-asparginase, dan
cyclophosphamid as non cytotoxic antibiotics usage.
Keywords: cytotoxic drugs,
children, glomerular filtration rate, Schwartz formula, CounahanBarratt formula
Penulis: Maria Wisnu Donowati,
Ayu Y.N. Pramodhawardani, Ika Lestari
Kode Jurnal: jpfarmasidd130302
