PERBANDINGAN EFEKTIVITAS HIPOGLIKEMIK OBAT METFORMIN PATEN DAN GENERIK BERLOGO BERDASARKAN PENURUNAN KADAR GLUKOSA DARAH MENCIT (Mus musculus) JANTAN YANG DIINDUKSI ALOKSAN
Abstrak: Diabetes mellitus
(DM) is a group of chronic diseases characterized by increased sugar levels in
the blood as a result of disturbances in the body's metabolic system.
Comparative studies have been conducted hypoglycemic effect of patent metformin
and generic branded metformin to the diabetic male mice with the aim to
determine the effect of the patent and the generic branded drug metformin drug
in lowering blood glucose levels. This study used male mice were divided into
three treatment groups, group I was given Na. CMC as a control, the group II
was given generic branded metformin and the group III was given patent
metformin. Measurement of blood glucose levels before and after induction of
alloxan 120 mg/kgbw intraperitoneally, and for 6 hours after drug
administration with measurements every 90 minutes interval. The data obtained were
analyzed by ANOVA. The results showed the patents metformin drug have no
significantly different effects compared to the generic branded metformin drug.
Penulis: Aulia Wati, Rachmat
Kosman, Assajadda Lizikri
Kode Jurnal: jpfarmasidd140383
