PHYSICAL CHARACTERIZATION OF IBUPROFEN-STEARIC ACID BINARY MIXTURE DUE TO COMPRESSION FORCE
Abstract: Aim of this research
is to determine physical characteristic of ibuprofen-stearic acid due to
compression force. Binary mixture of ibuprofen-stearic acid with weight ratio
of 4:6, 5:5, and 6:4 was compressed under various compression force using
hydraulic press with 13mm diameter flat punch.Identification of solid state
interaction between these two components was performed by Hot Stage Microscopy
(HSM). Physical characterization has been studied byDifferential Thermal
Analysis (DTA), X-ray Powder Diffraction (XRPD), Scanning Electron Microscopy
(SEM), and (Fourier Transform Infrared (FT-IR) spectroscopy. According to
hardness measurement, 4:6 weight ratio has the highest tensile strength on
170.6N/cm2 under 19.93kN compression force. Interaction identification by HSM
showed single blank line that indicates eutectic formation. Thermal analysis of
DTA also revealed eutectic formation upon compression whichthe endotermic peak
of ratio of 4:6has the lowest melting temperature of 53.2°C. X-ray diffraction
of three peaksgenerally showed that peak intensity decreases as compression
force increases, but at particular point it begins to increase again. Sintering
phenomenon at the surface of compressed tablet was observed from SEM analysis.
FT-IR study confirms the formation of simple eutectic.
Author: Dwi Setyawan, Dewi
Isadiartuti, Sita Desti Betari, Diajeng Putri Paramita
Journal Code: jpfarmasigg160021
Artikel Terkait :
Jp Farmasi gg 2016
- NATIONAL HEALTH COVERAGE SYSTEM : PHARMACISTS AND JKN PARTICIPANT SATISFACTION IN PRIMARY HEALTH FACILITIES
- Validation and Quantification of Theophylline and Salbutamol using Ion Pair Liquid Chromatography
- SYNTHESIS AND ANTIMICROBIAL EVALUATION OF 2-[(SUBSTITUEDPHENYL)-5-(1-PHENYL-3-(PIPERAZINYL)PYRIDO[3,2-f]QUINAZOLIN-4(1H)-YL]-1,3,4-THIADIAZOLES
- EVALUATION OF THE EFFECTIVENESS OF FREE NICOTINE PATCH THERAPY IN A CHARITY CLINIC FOR SMOKING CESSATION
- Ameliorative effects of vitamins C and E on tenofovir/nevirapine-induced hepatorenal oxidative stress in albino rats
- FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF ATENOLOL
- Modulatory effect of Drosera peltata J.E.Sm on development of metabolic syndrome in tumor bearing mice
- COMPARATIVE STANDARDIZATION OF MARKETED FORMULATIONS OF FERMENTED BIOMEDICINE – ARJUNARISTHA
- INFLUENCE OF POMEGRANATE JUICE ON THE CYP3A4-MEDIATED METABOLISM AND P-GLYCOPROTEIN MEDIATED TRANSPORT OF SAQUINAVIR IN VIVO AND EX VIVO MODELS
- ANTIOXIDANT ACTIVITY OF DRIED STRAWBERRY JUICES (Fragaria vesca L.) EMULGEL PREPARATION USING CANDLENUT OIL AND IT’S DIFFUSION
- ANTIDIABETIC ACTIVITY OF ETHANOLIC EXTRACT OF KALANCHOE PINNATA LEAVES IN ALLOXAN INDUCED HYPERGLYCAEMIC RATS
- MONOSODIUM GLUTAMATE EXPOSURE AT EARLY DEVELOPMENTAL STAGE INCREASES APOPTOSIS AND STEREOTYPIC BEHAVIOR RISKS ON ZEBRAFISH (DANIO RERIO) LARVAE
- THE EFFICACY OF DIFFERENT ORAL MAGNESIUM SUPPLEMENTS FOR MIGRAINE PREVENTION: A LITERATURE REVIEW
- OPTIMIZING STRUCTURE-BASED VIRTUAL SCREENING PROTOCOL TO IDENTIFY PHYTOCHEMICALS AS CYCLOOXYGENASE-2 INHIBITORS
- FORMULATION OF SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM OF BOVINE SERUM ALBUMIN USING HLB (HYDROPHILIC-LYPOPHILIC BALANCE) APPROACH
- CYTOTOXIC AND ANTI-VIRAL ACTIVITY OF Acacia catechu ON HUMAN PERIPHERAL BLOOD MONONUCLEAR CELLS
- SYNTHESIS AND ANALGETIC ACTIVITY EVALUATION OF 4-[N-(4-HYDROXYPHENYL)CARBOXYMIDOYL]-2-METHOXYPHENOL
- SYNTHESIS AND SCREENING OF SOME AZOMETHINES BEARING METHYL SALICYLATE MOIETY FOR ANTIBACTERIAL ACTIVITIES
- AN LC- MS/MS METHOD FOR THE DETERMINATION OF OMEPRAZOLE ON PROTON PUMP INHIBITOR IN HUMAN PLASMA
- ANTI-OXIDANT AND ANTI-DIABETIC ACTIVITIES OF ETHANOLIC EXTRACT OF Primula denticulata FLOWERS
- ANTIUROLITHIATIC ACTIVITY OF ETHANOLIC EXTRACT OF TAXILLUS TOMENTOSUS PLANT ON ETHYLENE GLYCOL AND AMMONIUM CHLORIDE INDUCED UROLITHIASIS IN WISTAR RATS
- PHYTOCHEMICAL CONSTITUENTS AND HYPOGLYCEMIC EFFECT OF GYMNEMIC ACID EXTRACTS FROM BIG AND SMALL LEAF VARIETIES OF Gymnema Sylvestre R.Br
- FORMULATION DEVELOPMENT AND CHARACTERIZATION OF TEA TREE OIL LOADED ETHOSOMES
- DETERMINATION OF SIBUTRAMINE ADULTERATED IN HERBAL SLIMMING PRODUCTS USING TLC DENSITOMETRIC METHOD