POTENSI TAPE SEBAGAI PANGANAN TRADISIONAL TERHADAP EFEK HEPATOTOKSIK TIKUS TERINDUKSI KARBON-TETRAKLORIDA
Abstract: The purpose of this
study was to determine the effect of “Tape” that has an alcoholic compound, to
the hepatotoxic effect in the rat induced Carbon Tetrachloride. And also
determine which fermentation time of the Tape can give effect to the
hepatotoxic in the rat induced Carbon tetrachloride. Healthy rats were randomly
divided into 7 groups of 5 animals in each. Group 1 received carbon
tetrachloride 2ml/kgBW treated intraperitoneal. Group 2-4 were given “Tape”
suspension 18g/kgBW once daily for 6 days with different fermentation time (3,
5, 7 days). Group 5-7 were given “Tape” suspension 18g/KgBW once daily for 6
days with different fermentation time and carbon tetrachloride was given on the
7th day. Blood sample from all groups was obtained by sinus orbitalis after 24 hours
application for estimation the serum level of transaminase. The result showed
that “Tape” suspension had a potential effect to reduce the hepatotoxicity
induced by carbon tetrachloride. “Tape” suspension with 5 days fermentation was
significantly decreased serum level of transaminase (P<0,05) upon carbon
tetrachlorideinduced hepatic damage in rats.
Penulis: Gidion Krisnadi
Yoseph, Christiana Destia Anggraeni, Ni Luh Putu Dian Prawita Putri, Phebe
Hendra
Kode Jurnal: jpfarmasidd130312
