STRUCTURE–ANTIMICROBIAL PROPERTIES STUDY OF SOME DIBASIC PHENYLCARBAMIC ACID ESTERS
Abstract: Due to worldwide
phenomenon of microbial resistance to commonly used therapeutic agents,
antibiotics and antifungals, dibasic di‑/trimethylphenylcarbamic
acid esters 1–3, a non-traditional series of potential antimicrobials, has been
in vitro evaluated against chosen Gram-positive (Staphylococcus aureus) and
Gram-negative (Escherichia coli) bacterial strains as well as against
yeast (C. albicans) by the minimum inhibitory concentration (MIC) assay. Taking
into consideration chemical structure of tested derivatives, the incorporation
of more than one protonated atom of nitrogen into salt forming fragment
positively influenced the activity against E. coli. On the contrary, the
presence of one or more methyl groups instead of 3-alkoxy side chain attached
to lipophilic aromatic moiety has not found to be favorable structural feature.
In entire set of inspected compounds, the most promising results have been
found for the compound 3,
chemically1-[3-piperidinium-1-yl-2-({[(2,4,6-trimethylphenyl)amino]carbonyl}oxy)propyl]
piperidinium dichloride, against E. coli with the MIC=1.56 mg/mL.
Author: Ivan Malík, Jozef
Csöllei, Marián Bukovský
Journal Code: jpfarmasigg160018
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