SYNTHESIS AND SCREENING OF SOME AZOMETHINES BEARING METHYL SALICYLATE MOIETY FOR ANTIBACTERIAL ACTIVITIES
Abstract: In this study, the
series of novel azomethines were synthesized from methyl salicylate and their
structural determination was done by IR, NMR and mass spectral data. The
screening of these synthesized compounds were done against some Gram positive
and Gram negative bacteria in DMF and DMSO solvents by agar disc method. It is
observed that solvent and compound structure both affect the inhibition. DMF is
found to be good solvent in the present study. Amongst all studied compounds,
JB-4 showed maximum zone of inhibition against most of the studied bacterial
strains while compound JB-2 is least effective. Thus, substitution affects
inhibition and methyl salicylate moiety with cinnamaldehyde side chain is most
effective. Further, virtual screening of these compounds was done to evaluate
molecular properties and bioactive scores of these compounds.
Author: Shipra Baluja, Sumitra
Chanda
Journal Code: jpfarmasigg160028
Artikel Terkait :
Jp Farmasi gg 2016
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