Uji Disolusi Beberapa Tablet Parasetamol yang Ada di Perdagangan
Abstract: The dissolution test
four generic tablets and one branded name of parasetamol tablets has been
undertaken. Method applied was in the paddle method as required by Pharmacopea
of Indonesian ed. IV. Paracetamol concentration measured spectrophotometrically
at maximum wave length of 243 nm in dissolution medium pH 5.8 phosphate buffer
solution. The result dissolution test to comply with tolerance is not less than
80% of the labeled amount of paracetamol is dissolved in tweenty minutes. The
dissolution about drown from the plot between percentage of paracetamol
dissolved versus time.The percentage of paracetamol dissolved at T30 analyzed
by using ANOVA test. Result showed in the dissolution rates between generic
1,2,3,4 and branded name were significant different take. Then continued to
DUNNET test , only generic 2 tablets was not significantly difference whereas
the other generic tablets were significant differences.
Penulis: Maria Dona Octavia,
Resita Sandra, Auzal Halim
Kode Jurnal: jpfarmasidd090059
