UJI EFEK ANTIINFLAMASI EKSTRAK n-HEKSAN DAUN BERUWAS LAUT (Scaevola taccada (Gaertn.) Roxb) PADA MENCIT JANTAN (Mus musculus) YANG DIINDUKSI DENGAN KARAGEN
Abstrak: This research about
antiinflammation effect from n-hexane extract of Beruwas Laut leaves (Scaevola
taccada (Gaertn.) Roxb.) in male mice (Mus musculus) was conducted, the aim was
assay the antiinflammation effect of Beruwas Laut leaves done extract based on
decrease in edema volume of foot palm male mice. This research using 15 male
mice that evaluated and divided into 5 groups that each group has 3 mice. In
group I, diclofenac sodium as the compare administrated. In groups II, III, dan
IV, n-hexane Extract of Beruwas Laut
leaves in concentration of 2,5%, 5% and 7,5% administrated. In group V, 1%
Na-CMC as negative control administrated. Induction carried out by injection 1%
w/v carrageen 0,1 ml subcutan on the feet palm of mice. One hour later each
group administered the preparation test 1 ml/30 gBW orally. The measurement of
edema volume carried out prior and after administration of the tested
preparation 0, 30, 60, 90, and 120 minutes. The data correlation between
induction and antiinflammation effect analysed. Result indicated variety with
n-hexane extract of Beruwas Laut leaves have the antiinflammation effect at
concentration 7,5%.
Penulis: Sitti Amirah, Rahmawati,
Safriani Rahman, Franita Achmad
Kode Jurnal: jpfarmasidd140395
