Efek Paparan Rhodamin B Terhadap Perubahan Makroskopis Dan Histopatologi Mukosa Kolon Mencit Jantan (Mus musculus L.)
Abstract: Rhodamine B is a
synthetic dye that can not be used as food additives and harmful if it enters
the body, causing oxidative stress if continued resulting in cell membrane
damage and cell death, but until now its use is still found in industrial-scale
food production and household . The aim of research to determine the effect of
rhodamine B exposure and after cessation of exposure rhodamine B (recovery
period) to the macroscopic and histopathological changes in the colonic mucosa
of mice (Mus musculus L.) males. This study tested an experimental laboratory
to design the post-test only control group. The research subject of male mice
(Mus musculus L.) strains DD Webster, 6-7 weeks, 25-40 grams, 28 were divided 2
treatment groups: (1) P0 (control) were given distilled water 0,3ml, (2)
rhodamine B dose 0.2% / day, 0,3ml. Treatment for 21 days, then continued for 7
days without any treatment to see his cell recovery. The results showed a
significant increase (p <0.5) macroscopic colonic damage and histopathology
colonic mucosa in the treatment group compared with the control group when
treated well after treatment is stopped. Expected to society, especially with
children under five and school age do not consume snacks bright.
Penulis: Novita Aryani
Kode Jurnal: jpkimiadd150629
