APPLICATION OF ION-EXCHANGE RESIN COLUMN FOR BASIC DEVELOPMENT OF STRONTIUM-90/YTTRIUM-90 GENERATOR FOR PREPARATION OF RADIOPHARMACEUTICAL THERAPY
ABSTRACT: The aim of this
study is to examine the possible use of ion-exchange resin on Dowex AG 50x8 in
separating Y-90 from Sr-90 which then could be applied in the basic of
manufacture of producing Sr-90/Y-90 generator for the production of
radiopharmaceutical cancer therapy. The findings showed that a distributive
coefficient of Sr-90 and Y-90 with HCl 6 N solvent showed that distributive
coefficient of Sr-90 in cation-exchange resin on Dowex 50x8 was greater than
Y-90. Y-90 in HCl 6 N solvent was more easily eluted, while Sr-90 was bound to
resin.. In conclusion, resin on Dowex AG 50x8 with HCl 6 N elution solvent
might be able to separate Y-90 from Sr-90 as the basis for Sr-90/Y-90
generator.
Author: Muchtaridi, Elvan
Kamal, Anas Subarnas, Abdul Mutalib
Journal Code: jpkimiagg170021
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