Cinnamic Acid Derivatives as α-Glucosidase Inhibitor Agents
ABSTRACT: Diabetes mellitus is
a metabolic disorder of carbohydrate metabolism. Treatment of type II diabetes
is usually done by prescribing diet and exercise for the patient however it can
also be treated with antidiabetic drugs. The purpose of this paper is to
illustrate some cinnamic acid derivative compounds which are either isolated
from natural materials or the results of the chemical synthesis. In addition,
their biological activities as an agent of α-glucosidase inhibitors have also
been evaluated. Chemically, cinnamic acid has three main functional
groups: first is the substitution on the
phenyl group, second is the additive reaction into the α-β unsaturated, and
third is the chemical reaction with carboxylic acid functional groups. Chemical
aspects of cinnamic acid derivative compounds have received much attention in
the research and development of drugs, especially modifications within three
functional groups are very influential. In the last 10 years, a lot of research
and development of cinnamic acid derivatives as inhibitors of the α-glucosidase
enzyme has been done. One example of the research done in this field is the
modification of para position in the structure of cinnamic acid and addition of
alkyl groups in the carboxylic group which would increase the activity of the
α-glucosidase enzyme therefore the level of inhibition is 100 times higher than
that of cinnamic acid compound itself. The novelty of this review article is to
focus on the antidiabetic activity of cinnamic acid derivatives.
KEYWORDS: Diabetes mellitus;
insulin; hyperglycemia; cinnamic acid; derivatives cinnamic acid; agent
α-glucosidase inhibitors
Author: Teni Ernawati, Maksum
Radji, Muhammad Hanafi, Abdul Mun’im, Arry Yanuar
Journal Code: jpkimiagg170025
