SYNTHESIS AND IN VITRO EVALUATION OF C-METHYLCALIX[4]RESORCINARYL OCTACINNAMATE AS THE SUNSCREEN
ABSTRACT: Synthesis and in
vitro test of C-methylcalix[4]resorcinaryl octacinnamate as the sunscreen has
been conducted. The C-methylcalix[4]resorcinaryl octacinnamate was synthesized
in 2 steps. They were synthesis of C-methylcalix[4]resorcinarene via acid
catalyzed condensation of resorcinol and acetaldehyde, followed by
estherification using cinnamoyl chloride and pyridine catalyst. The
characterization of the target molecule was performed by infra red
spectrophotometer, proton-NMR, carbon-NMR and mass spectromether. The sunscreen
activity test was conducted by spectroscopic method and MTT-assay.
Spectroscopic analysis (UV) showed that the target molecule absorbed the
dangerous ultraviolet radiation between 280 and 320 nm (UV B) wave length with
the maximum absorption at 290 nm (ε = 31.535 M-1 cm-1). The MTT-assay indicated
that the IC50 of C-methylcalix[4]resorcinaryl octacinnamate is 12.006 ppm. The
sunscreen activity of C-methylcalix[4]resorcinaryl octacinnamate is stronger
than commercial sunscreen Intersun (IC50 = 18.235 ppm).
Author: Budiana I Gusti M.
Ngurah, Jumina, Chairil Anwar, Sunardi, Mustofa
Journal Code: jpkimiagg170033
