PENGARUH KONSENTRASI K2SO4TERHADAP DRUG LOADING ASAM SALISILAT PADA PECTIN EDIBLE FILM
Abstract: Waste from orange
peel contains pectin that can be utilized as raw material to produce drug
delivery system membrane for various types of drugs. Drug loading and release
behavior of the membrane can be controlled by adding crosslinker (K2SO4). This
research aimed to study the effect of crosslinker composition to the salicylic
acid loading as an example of antibiotics. Pectin was dissolved in water, mixed
with plasticizers and the variation of K2SO4 solution were 0, 0.1, and 0.2 g /
mL at temperature 66°C. The mixture was dried in an oven at temperature 50°C
for about 15 hours. The analysis have been done were drug loading, gel sweeling
and FTIR. The results show that the more concentration of crosslinker added,
the loading of salicylic acid were influenced in range 0.031 – 0.045 g/mL. The
parameters estimated by adding K2SO4 crosslinker were gel swelling in range
0,11-0,29 g, whereas FTIR analysis has not significant changein each
concentration.
Penulis: Lilis Kistriyani,
Rachman Dwi Nugroho, Morgan Primawan
Kode Jurnal: jptindustridd160109
