Association Between Degree of Gastritis and Malondialdehyde Level of Gastritis Patients at Adam Malik General Hospital Medan
Abstract: The main
pathogenesis of gastritis is inflammation which process can not be separated
from the role of free radicals. Malondialdehyde (MDA) is a free radical
biomarker and which increases in gastritis patients. However, studies on MDA
were generally performed on experimental animals or examined MDA in gastric
mucosa. The aim of this study is to determine the association of
histopathological degrees of gastritis (the degree of lymphocyte infiltration,
neutrophil activity, atrophy, and intestinal metaplasia) with plasma MDA level.
Method: Cross-sectional study of 40 consecutive gastritis patients who
came to endoscopic unit of Adam Malik General Hospital Medan, from January to
May 2017. Assessment for the severity of chronic inflammation, neutrophil
activity, atrophy, and intestinal metaplasia refers to Updated Sydney System.
Plasma MDA levels were examined using an HPLC MDA kit. Univariate and bivariate
(Chi-square and fisher exact test) analysis were performed with SPSS version
22.
Results: A total of 26 patients (65%) were men with an average age of
49.25 years. Lymphocyte infiltration was observed in 100% of specimens,
neutrophil infiltration in 37.5%, atrophy in 22.5%, and intestinal metaplasia
in 22.5%. There was a significant association between degree of lymphocyte
infiltration with MDA level (p = 0.014; PR = 8.667; 95% CI: 1.52-89.52). There
was a significant association between degree of neutrophil activity with high
MDA level (p = 0.002; PR = 11.33; 95% CI: 2.64-48.74). There was a significant
association between degree of atrophy with high level of MDA (p < 0.001; PR
= 14; 95% CI: 3.4–57.648). There was a significant association between degree
of intestinal metaplasia with high MDA level (p = 0.001; PR = 12.5; 95% CI:
3.76-24).
Conclusion: There were significant associations between degree of
lymphocyte infiltration, neutrophil activity, atrophy, and intestinal
metaplasia with high level of MDA.
Keywords: gastritis,
Malondialdehyde, Updated Sydney System
Author: Darmadi, Gontar
Alamsyah Siregar, Leonardo Basa Dairi
Journal Code: jpkedokterangg170382
