Association Between Degree of Gastritis and Malondialdehyde Level of Gastritis Patients at Adam Malik General Hospital Medan

Abstract: The main pathogenesis of gastritis is inflammation which process can not be separated from the role of free radicals. Malondialdehyde (MDA) is a free radical biomarker and which increases in gastritis patients. However, studies on MDA were generally performed on experimental animals or examined MDA in gastric mucosa. The aim of this study is to determine the association of histopathological degrees of gastritis (the degree of lymphocyte infiltration, neutrophil activity, atrophy, and intestinal metaplasia) with plasma MDA level.

Method: Cross-sectional study of 40 consecutive gastritis patients who came to endoscopic unit of Adam Malik General Hospital Medan, from January to May 2017. Assessment for the severity of chronic inflammation, neutrophil activity, atrophy, and intestinal metaplasia refers to Updated Sydney System. Plasma MDA levels were examined using an HPLC MDA kit. Univariate and bivariate (Chi-square and fisher exact test) analysis were performed with SPSS version 22.

Results: A total of 26 patients (65%) were men with an average age of 49.25 years. Lymphocyte infiltration was observed in 100% of specimens, neutrophil infiltration in 37.5%, atrophy in 22.5%, and intestinal metaplasia in 22.5%. There was a significant association between degree of lymphocyte infiltration with MDA level (p = 0.014; PR = 8.667; 95% CI: 1.52-89.52). There was a significant association between degree of neutrophil activity with high MDA level (p = 0.002; PR = 11.33; 95% CI: 2.64-48.74). There was a significant association between degree of atrophy with high level of MDA (p < 0.001; PR = 14; 95% CI: 3.4–57.648). There was a significant association between degree of intestinal metaplasia with high MDA level (p = 0.001; PR = 12.5; 95% CI: 3.76-24).

Conclusion: There were significant associations between degree of lymphocyte infiltration, neutrophil activity, atrophy, and intestinal metaplasia with high level of MDA.

Keywords: gastritis, Malondialdehyde, Updated Sydney System

Author: Darmadi, Gontar Alamsyah Siregar, Leonardo Basa Dairi

Journal Code: jpkedokterangg170382

Artikel Terkait :

Jp Kedokteran gg 2017

• Disseminated Histoplasmosis in an Indonesian HIV-Positive Patient: A Case Diagnosed by Fine Needle Aspiration Cytology
• ST Elevation in Lead aVR and Its Association with Clinical Outcomes
• A Rare Case Series of Ischemic Stroke Following Russell’s Viper Snake Bite in India
• Current and Emerging Therapy on Lupus Nephritis
• Dengue Hemorrhagic Fever with Acute Fulminant Hepatitis: A Case Report
• Intralesion Triamcinolon Injection Therapy on Esophageal Stricture as Side Effect of Long Term Use Biphosphonate
• Alcoholic Liver Cirrhosis in Young Female: Diagnostic and Therapeutic Challenge
• Long Term Risks of Proton Pump Inhibitor Administration: A Literature Review
• Artificial Ascites in Radiofrequency Ablation for Liver Cancer
• The Role of Biologics Agent in the Treatment of Inflammatory Bowel Disease
• Celiac Disease
• Correlation of Aerobic Exercise and High Nitrate Diet with Population of Eschericia coli in the Digestive Tract of Liver Cirrhosis Individuals
• Incidence of Colorectal Cancer in Saiful Anwar Hospital, Malang January 2010- April 2015
• The Comparison of Tnf α (Tumor Necrosis Factor α) Serum Levels Between Cytotoxin - Associated Gene A (Caga) Positive and Negative in Patients with Gastritis Helicobacter pylori
• Serial Case: Colorectal Malignancy in Young Age
• Diagnostic Findings of Sclerosing Mesenteritis and the Disease Correlations with Caecal Adenocarcinoma
• Small Bowel Malignancy in Patient with Obscure Gastrointestinal Bleeding in Cipto Mangunkusumo Hospital, Diagnosed Using Double Balloon Enteroscopy: A Case Series
• Precancerous Lesions in Gastrointestinal Tract
• National Consensus on the Use of Sedation Drugs in the Gastrointestinal Endoscopic Procedures
• Hepatitis B Reactivation in Immunosupressed Patients, Prophylaxis and Management
• The Association between Metaplasia and Gastric Malignancy with Helicobater pylori Infection
• Correlation of Carcinoma Percentage (CP) in Colorectal Adenocarcinoma with Several Clinical Pathological Aspects in Anatomical Pathology Department Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital Jakarta in Year 2012-2013
• Microscopic Examination of Fecal Leukocytes as a Simple Method to Detecting Infective Colitis in Children
• Successful Therapy in A 20 Years Old Male with Acute Pancreatitis