Comparison of Alpha-Fetoprotein Level in Varying Severity Degree of Hepatocellular Carcinoma Assesed with the Barcelona Clinic of Liver Cancer During 2015-2016 in Haji Adam Malik General Hospital Medan
Abstract: Hepatocellular
carcinoma (HCC) is one of the leading causes of cancer-related deaths
worldwide. Presently, the reference staging system to evaluate the prognosis of
HCC is The Barcelona Clinic Liver Cancer (BCLC) system. The aim of the study
was to identify the comparison of alpha-fetoprotein (AFP) level in varying
severity degree of HCC patient assessed with BCLC.
Method: This retrospective observational study used patients’ medical
record hospitalized for HCC between January 1st 2015 until December 31st 2016
in Adam Malik Hospital. From 166 HCC patients with AFP, liver function test
(LFT), home sleep test (HST), ultrasonography (USG), and computerized
tomography (CT) scan liver 3 phase were included in this study. The comparison
of AFP in severity of HCC based on BCLC system was analyzed.
Results: About 77.7% HCC patients were male. The mean age was 52 ± 13.63
years. The most cause of HCC was hepatitis B infection. Median AFP was 574.97
ng/mL. According to the BCLC staging system, 12 patients were classified as
stage A (7.2%), 54 patients stage B (32.5%), 76 patients stage C (45.8%) and 24
patients stage D (14.5%). There’s significance difference value of AFP in
varying stage of BCLC for HCC, which the highest value in BCLC stage D,
followed by C, B and A (p = 0,001)
Conclusion: There’s significance difference value of AFP in varying stage
of BCLC for HCC patients.
Keywords: hepatocellular
carcinoma; alpha-fetoprotein; BCLC system
Author: Gontar Alamsyah
Siregar, Sri Ningsih Lubis
Journal Code: jpkedokterangg170374
