Correlation of Aerobic Exercise and High Nitrate Diet with Population of Eschericia coli in the Digestive Tract of Liver Cirrhosis Individuals
Abstract: In liver cirrhosis,
the population of E coli is increased. conditions such as reduced intestinal).
Escherichia coli with 2 enzyme nitrate reductase (NRF and Nir) reduce nitrate
to nitrite and subsequently converted to ammonia (99%) and nitric oxide (1%) in
anaerobic condition. Regular aerobic exercise 2-3 times/week for 30 minutes
resulted in increased 2,3-DPG which reduces the activity of E. coli to reduce
nitrate to nitrite and ammonia, which only works on the anaerobic state. High
Nitrate Diets lead to increased nitrate reducing bacteria such as E. coli
resulting in the reduction of nitrate excess produce nitrite and ammonia in
large quantities. Probiotic Lactobacillus spp. can suppress the growth of
bacterial endotoxins and pathogens such as E. coli and other
Enterobacteriaceae. This study aimed to determine the correlation of aerobic
exercise and a high nitrate diet in gastrointestinal populations of Escherichia
coli gastrointestinal tract in patient with liver cirrhosis.
Method: This was a descriptive-experimental study in liver cirrhosis
patients Child Pugh A/B in outpatient clinic Saiful Anwar Hospital in August
2015. Respondents were asked to fill out a questionnaire with information about
the demographic data, the nitrate diet, aerobic exercise, other medical data
and sanitation, and stool samples were taken for faecal culture. Eta
Correlation statistical test was used to determine the correlation of aerobic
exercise and a high nitrate diet high in population of E. coli. The significant
difference are indicated by p < 0.005.
Results: A total of 36 patients diagnosed with liver cirrhosis Child Pugh
A/B, 14 (39%) underwent aerobic exercise 3x /week, as many as 25 (70%) consume
a high nitrate diet. There was a strong relationship between aerobic exercise
and high nitrate diet with population of E. coli (Ƞ = 0.725; p < 0.05).
Conclusion: There was a strong relationship between aerobic exercise and
high nitrate diet with a population of E. coli in liver cirrhosis. Giving
probiotics in patients with liver cirrhosis suppressed the population of E.
coli.
Keywords: Aerobic exercise;
high nitrate diet; Escherichia coli; liver cirrhosis
Author: Retti Nurlaili, Syifa
Mustika
Journal Code: jpkedokterangg170393
