Correlation of Carcinoma Percentage (CP) in Colorectal Adenocarcinoma with Several Clinical Pathological Aspects in Anatomical Pathology Department Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital Jakarta in Year 2012-2013
Abstract: Colorectal carcinoma
is malignant tumour of the large intestinal epithelial, where more than 90% of
colorectal carcinoma is adenocarcinoma. Desmoplastic stroma in primary tumour
holds an important role in tumour development process. Mesker et al described
carcinoma percentage (CP) evaluation in routine preparations with
Haematoxylin-eosin (HE) staining as one of the prognostic factors.
Method: This retrospective study was performed by collecting forms and
slides of colorectal carcinoma resection cases from the archives of Anatomical
Pathology Department FMUI-CMGNH in 2 years period (2012-2013). Collection of
clinical data and re-evaluation of HE slides by 2 people which were the writer
and supervisor were performed to determine CP value by observing the comparison
between tumour percentage and desmoplastic stroma.
Results: We included 92 cases of colorectal adenocarcinoma within those 2
years period (2012-2013). Comparison of total cases between male and female was
3:2, age > 40 years old were the most commonly found; in regard to location
in the colon, most were found in the left side compared to the right side of
the colon with the ratio of 3:7. Tumour histological grading with good
differentiation were the most commonly found and most pT value being found were
pT3; most lymph node involvement was N1. The most CP value attained in every
parameter was CP-Low.
Conclusion: Carcinoma percentage (CP) which was divided as CP-High and
CP-Low could be used as a prognostic factor. In this study, we found more cases
of CP-Low compared to CP-High, either based on sex, age, location, degree of
differentiation, pT value, or even lymph node involvement. CP-Low which showed
worse prognosis could also be used as a marker of patients who were at higher
risk of colorectal carcinoma.
Keywords: colorectal
carcinoma; carcinoma percentage (CP); CP-Low, CP-High
Author: Elisabeth Indria Sari,
Ening Krisnuhoni
Journal Code: jpkedokterangg170383
