Correlation of Carcinoma Percentage (CP) in Colorectal Adenocarcinoma with Several Clinical Pathological Aspects in Anatomical Pathology Department Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital Jakarta in Year 2012-2013
Abstract: Colorectal carcinoma
is malignant tumour of the large intestinal epithelial, where more than 90% of
colorectal carcinoma is adenocarcinoma. Desmoplastic stroma in primary tumour
holds an important role in tumour development process. Mesker et al described
carcinoma percentage (CP) evaluation in routine preparations with
Haematoxylin-eosin (HE) staining as one of the prognostic factors.
Method: This retrospective study was performed by collecting forms and
slides of colorectal carcinoma resection cases from the archives of Anatomical
Pathology Department FMUI-CMGNH in 2 years period (2012-2013). Collection of
clinical data and re-evaluation of HE slides by 2 people which were the writer
and supervisor were performed to determine CP value by observing the comparison
between tumour percentage and desmoplastic stroma.
Results: We included 92 cases of colorectal adenocarcinoma within those 2
years period (2012-2013). Comparison of total cases between male and female was
3:2, age > 40 years old were the most commonly found; in regard to location
in the colon, most were found in the left side compared to the right side of
the colon with the ratio of 3:7. Tumour histological grading with good
differentiation were the most commonly found and most pT value being found were
pT3; most lymph node involvement was N1. The most CP value attained in every
parameter was CP-Low.
Conclusion: Carcinoma percentage (CP) which was divided as CP-High and
CP-Low could be used as a prognostic factor. In this study, we found more cases
of CP-Low compared to CP-High, either based on sex, age, location, degree of
differentiation, pT value, or even lymph node involvement. CP-Low which showed
worse prognosis could also be used as a marker of patients who were at higher
risk of colorectal carcinoma.
Keywords: colorectal
carcinoma; carcinoma percentage (CP); CP-Low, CP-High
Author: Elisabeth Indria Sari,
Ening Krisnuhoni
Journal Code: jpkedokterangg170383
Artikel Terkait :
Jp Kedokteran gg 2017
- Disseminated Histoplasmosis in an Indonesian HIV-Positive Patient: A Case Diagnosed by Fine Needle Aspiration Cytology
- ST Elevation in Lead aVR and Its Association with Clinical Outcomes
- A Rare Case Series of Ischemic Stroke Following Russell’s Viper Snake Bite in India
- Current and Emerging Therapy on Lupus Nephritis
- Dengue Hemorrhagic Fever with Acute Fulminant Hepatitis: A Case Report
- Intralesion Triamcinolon Injection Therapy on Esophageal Stricture as Side Effect of Long Term Use Biphosphonate
- Alcoholic Liver Cirrhosis in Young Female: Diagnostic and Therapeutic Challenge
- Long Term Risks of Proton Pump Inhibitor Administration: A Literature Review
- Artificial Ascites in Radiofrequency Ablation for Liver Cancer
- The Role of Biologics Agent in the Treatment of Inflammatory Bowel Disease
- Celiac Disease
- Correlation of Aerobic Exercise and High Nitrate Diet with Population of Eschericia coli in the Digestive Tract of Liver Cirrhosis Individuals
- Incidence of Colorectal Cancer in Saiful Anwar Hospital, Malang January 2010- April 2015
- The Comparison of Tnf α (Tumor Necrosis Factor α) Serum Levels Between Cytotoxin - Associated Gene A (Caga) Positive and Negative in Patients with Gastritis Helicobacter pylori
- Serial Case: Colorectal Malignancy in Young Age
- Diagnostic Findings of Sclerosing Mesenteritis and the Disease Correlations with Caecal Adenocarcinoma
- Small Bowel Malignancy in Patient with Obscure Gastrointestinal Bleeding in Cipto Mangunkusumo Hospital, Diagnosed Using Double Balloon Enteroscopy: A Case Series
- Precancerous Lesions in Gastrointestinal Tract
- National Consensus on the Use of Sedation Drugs in the Gastrointestinal Endoscopic Procedures
- Hepatitis B Reactivation in Immunosupressed Patients, Prophylaxis and Management
- The Association between Metaplasia and Gastric Malignancy with Helicobater pylori Infection
- Association Between Degree of Gastritis and Malondialdehyde Level of Gastritis Patients at Adam Malik General Hospital Medan
- Microscopic Examination of Fecal Leukocytes as a Simple Method to Detecting Infective Colitis in Children
- Successful Therapy in A 20 Years Old Male with Acute Pancreatitis