Hepatitis B Reactivation in Immunosupressed Patients, Prophylaxis and Management
Abstract: Hepatitis B virus
(HBV) reactivation is a clinical problem associated with high morbidity and
mortality rates. Currently, this incidence seems to be increasing around the
world. The reactivation commonly developes in immunosuppressed individuals,
although it may also occur spontaneously. Individuals who develop malignancy
with chronic hepatitis B virus infection are at high-risk for hepatitis B virus
reactivation, since they are closely related to immunosuppression, especially
when undergoing chemotherapy. The loss of immune control in these patients may
results in the reactivation of HBV replication within hepatocytes. This review
article will focus on HBV reactivation related to immunosuppressed patients,
immunosuppressive drug classes and corresponding risk estimates of hepatitis B
virus reactivation, screening test recommended before getting this drugs,
choice of antiviral drugs for prophylaxis, and duration of prophylaxis
treatment based on EASL, AASLD and APASL guidelines.
Keywords: hepatitis B
reactivation, immunosuppresive; chemotherapy; prophylaxis; treatment
Author: Ulfa Kholili, Tri
Yanti
Journal Code: jpkedokterangg170385
