Hepatitis B Reactivation in Immunosupressed Patients, Prophylaxis and Management

Abstract: Hepatitis B virus (HBV) reactivation is a clinical problem associated with high morbidity and mortality rates. Currently, this incidence seems to be increasing around the world. The reactivation commonly developes in immunosuppressed individuals, although it may also occur spontaneously. Individuals who develop malignancy with chronic hepatitis B virus infection are at high-risk for hepatitis B virus reactivation, since they are closely related to immunosuppression, especially when undergoing chemotherapy. The loss of immune control in these patients may results in the reactivation of HBV replication within hepatocytes. This review article will focus on HBV reactivation related to immunosuppressed patients, immunosuppressive drug classes and corresponding risk estimates of hepatitis B virus reactivation, screening test recommended before getting this drugs, choice of antiviral drugs for prophylaxis, and duration of prophylaxis treatment based on EASL, AASLD and APASL guidelines.

Keywords: hepatitis B reactivation, immunosuppresive; chemotherapy; prophylaxis; treatment

Author: Ulfa Kholili, Tri Yanti

Journal Code: jpkedokterangg170385

Artikel Terkait :

Jp Kedokteran gg 2017

• Disseminated Histoplasmosis in an Indonesian HIV-Positive Patient: A Case Diagnosed by Fine Needle Aspiration Cytology
• ST Elevation in Lead aVR and Its Association with Clinical Outcomes
• A Rare Case Series of Ischemic Stroke Following Russell’s Viper Snake Bite in India
• Current and Emerging Therapy on Lupus Nephritis
• Dengue Hemorrhagic Fever with Acute Fulminant Hepatitis: A Case Report
• Intralesion Triamcinolon Injection Therapy on Esophageal Stricture as Side Effect of Long Term Use Biphosphonate
• Alcoholic Liver Cirrhosis in Young Female: Diagnostic and Therapeutic Challenge
• Long Term Risks of Proton Pump Inhibitor Administration: A Literature Review
• Artificial Ascites in Radiofrequency Ablation for Liver Cancer
• The Role of Biologics Agent in the Treatment of Inflammatory Bowel Disease
• Celiac Disease
• Correlation of Aerobic Exercise and High Nitrate Diet with Population of Eschericia coli in the Digestive Tract of Liver Cirrhosis Individuals
• Incidence of Colorectal Cancer in Saiful Anwar Hospital, Malang January 2010- April 2015
• The Comparison of Tnf α (Tumor Necrosis Factor α) Serum Levels Between Cytotoxin - Associated Gene A (Caga) Positive and Negative in Patients with Gastritis Helicobacter pylori
• Serial Case: Colorectal Malignancy in Young Age
• Diagnostic Findings of Sclerosing Mesenteritis and the Disease Correlations with Caecal Adenocarcinoma
• Small Bowel Malignancy in Patient with Obscure Gastrointestinal Bleeding in Cipto Mangunkusumo Hospital, Diagnosed Using Double Balloon Enteroscopy: A Case Series
• Precancerous Lesions in Gastrointestinal Tract
• National Consensus on the Use of Sedation Drugs in the Gastrointestinal Endoscopic Procedures
• The Association between Metaplasia and Gastric Malignancy with Helicobater pylori Infection
• Correlation of Carcinoma Percentage (CP) in Colorectal Adenocarcinoma with Several Clinical Pathological Aspects in Anatomical Pathology Department Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital Jakarta in Year 2012-2013
• Association Between Degree of Gastritis and Malondialdehyde Level of Gastritis Patients at Adam Malik General Hospital Medan
• Microscopic Examination of Fecal Leukocytes as a Simple Method to Detecting Infective Colitis in Children
• Successful Therapy in A 20 Years Old Male with Acute Pancreatitis