Long Term Risks of Proton Pump Inhibitor Administration: A Literature Review
Abstract: Proton pump
inhibitor (PPI) has become drug of choice for acid related disease. However,
PPI tend to be overprescribed and becoming one of the highest burden for health
cost. Some studies showed that PPI are prescribed unnecessarily. Recent
evidences showed raised concerns over long term effects of PPI consumption.
Several long term side effects such as increased incidence of gastric polyps,
micronutrient absorption disorders, infections, and osteoporosis have been
yearly discussed. In recent years there has been increased attention to new
side effects such as dementia, chronic renal failure, and cardiovascular
disorders. Therefore, some health associations had issued warning and guidance
regarding long term PPI prescription.
Keywords: Proton pump inhibitor;
long term side effect; polyp; infection; dementia; malabsorption; osteoporosis;
chronic kidney disease; cardiovascular
Author: Andi Kristanto, Randy
Adiwinata, Josephine Rasidi, Beatrice Belinda Phang, Sheila Adiwinata, Timoteus
Richard, Willy Brodus Uwan, Ari Fahrial Syam
Journal Code: jpkedokterangg170397
