Precancerous Lesions in Gastrointestinal Tract

Abstract: Gastrointestinal cancer is one of the health problems which is frequently found in many people in the world until now. Studies in gastrointestinal cancer showed early detection can reduce morbidity and improve the survival of patients. The precancerous lesions of the gastrointestinal tract are highly potential turn into cancer. Precancerous lesions can be defined as a change or non-cancerous lesions that can become cancerous over time.  Precancerous lesions can be found on the entire upper and lower gastrointestinal tract. Precancerous lesions of the upper digestive tract that can be found are Barrett's esophagus, chronic gastritis with or without Helicobacter pylori infection, atrophic gastritis, intestinal metaplasia of the gastric mucosa, epithelial dysplasia, and adenoma polyp. While precancerous lesions in the lower gastrointestinal tract are adenoma, inflammatory bowel disease, chronic infection and hereditary non-polyposis colon lesions. Precancerous lesions of the stomach in the form of chronic atrophic gastritis, intestinal metaplasia and dysplasia can be treated with anti-inflammatory and anti-free radical drugs such as rebamipide and superoxide dysmutase. Precancerous lesions in the colon in the form of chronic enterocolitis, dysplasia can be treated with anti-oxidants, anti-inflammatory and anti-free radical such as anti-oxidants, rebamipide, superoxide dismutase, anti-inflammatory drugs.

Keywords: precancerous lesions, gastrointestinal tract; intestinal metaplasia; dysplasia

Author: Marcellus Simadibrata, Randy Adiwinata

Journal Code: jpkedokterangg170387

Artikel Terkait :

Jp Kedokteran gg 2017

• Disseminated Histoplasmosis in an Indonesian HIV-Positive Patient: A Case Diagnosed by Fine Needle Aspiration Cytology
• ST Elevation in Lead aVR and Its Association with Clinical Outcomes
• A Rare Case Series of Ischemic Stroke Following Russell’s Viper Snake Bite in India
• Current and Emerging Therapy on Lupus Nephritis
• Dengue Hemorrhagic Fever with Acute Fulminant Hepatitis: A Case Report
• Intralesion Triamcinolon Injection Therapy on Esophageal Stricture as Side Effect of Long Term Use Biphosphonate
• Alcoholic Liver Cirrhosis in Young Female: Diagnostic and Therapeutic Challenge
• Long Term Risks of Proton Pump Inhibitor Administration: A Literature Review
• Artificial Ascites in Radiofrequency Ablation for Liver Cancer
• The Role of Biologics Agent in the Treatment of Inflammatory Bowel Disease
• Celiac Disease
• Correlation of Aerobic Exercise and High Nitrate Diet with Population of Eschericia coli in the Digestive Tract of Liver Cirrhosis Individuals
• Incidence of Colorectal Cancer in Saiful Anwar Hospital, Malang January 2010- April 2015
• The Comparison of Tnf α (Tumor Necrosis Factor α) Serum Levels Between Cytotoxin - Associated Gene A (Caga) Positive and Negative in Patients with Gastritis Helicobacter pylori
• Serial Case: Colorectal Malignancy in Young Age
• Diagnostic Findings of Sclerosing Mesenteritis and the Disease Correlations with Caecal Adenocarcinoma
• Small Bowel Malignancy in Patient with Obscure Gastrointestinal Bleeding in Cipto Mangunkusumo Hospital, Diagnosed Using Double Balloon Enteroscopy: A Case Series
• National Consensus on the Use of Sedation Drugs in the Gastrointestinal Endoscopic Procedures
• Hepatitis B Reactivation in Immunosupressed Patients, Prophylaxis and Management
• The Association between Metaplasia and Gastric Malignancy with Helicobater pylori Infection
• Correlation of Carcinoma Percentage (CP) in Colorectal Adenocarcinoma with Several Clinical Pathological Aspects in Anatomical Pathology Department Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital Jakarta in Year 2012-2013
• Association Between Degree of Gastritis and Malondialdehyde Level of Gastritis Patients at Adam Malik General Hospital Medan
• Microscopic Examination of Fecal Leukocytes as a Simple Method to Detecting Infective Colitis in Children
• Successful Therapy in A 20 Years Old Male with Acute Pancreatitis