The Role of Fecal M2-Pyruvate Kinase (M2-PK) in Colorectal Cancer Screening
Abstract: Colorectal cancer is
a malignancy with high incidence and mortality rate. The long carsinogenesis
sequence from adenoma unto carsinoma enable early detection and screening as
part of the management but until recently the commercialy available test has low
sensitivity and specificity. M2-pyruvate kinase (M2-PK), an isomer of
glycolisis enzyme involved in aerobic metabolism, is found in high amount in
cancerous cell and is shed unto luminal mucosa in colorectal cancer.
Quantification of this protein in feces is a promising method to detect
malignant lesion of colon. Several studies until recently demonstrate moderate
sensitivity and specificity but clearly with better performance than
commonly-used gFOBT.
Keywords: M2-pyruvate kinase;
M2-PK; fecal; colorectal cancer; screening
Author: Nur Chandra Bunawan,
Marcellus Simadibrata
Journal Code: jpkedokterangg170379
