Faktor risiko dan asupan isoflavon pada pasien kanker payudara
Abstract: Breast cancer is
noncommunicable chronic disease the prevalence of which is increasing all over
the world, including in Indonesia and particularly East Java. Causes of breast
cancer are unknown. Some studies show risk factors for breast cancer are
hormonal, genetic, reproductive and endocrinologic factors. There is the
isoflavon compound in soybeans that is known as anti-cancer with anti-estrogen
activities.
Objective: The study was aimed at identifying risk factor and the
difference of isoflavone intake between breast cancer patients and healthy
people in hospitals.
Method: The study was analytic observational using matched case-control
study design at comparison 1:2 with matching on a status of menopause. Cases
were positive receptor estrogen breast cancer patients newly diagnosed during
the first visit at hospital outpatient Oncologic Surgery Polyclinic. Controls
were staff considered healthy based on the result of health examination at Dr.
Ramelan Naval Hospital of Surabaya. Cases comprised 49 people and control 98
people taken through consecutive method. Data consisted of an identity of
samples, weight, height, isoflavone intake, family history, use of hormone
replacement therapy and parity. Intake of isoflavones was obtained from
semiquantitative food frequency questionnaire (SQ-FFQ) and statistical test
used Chi-Square and Odd Ratio (OR).
Results: There was the difference in isoflavone intake and family history
between cases and controls (p<0.05) and there was an association between
isoflavone intake (OR=2.58; p=0.007) and family history (OR=18; p=0.002) and
the incidence of breast cancer. There was no association between the status of
obesity, parity, and use of hormone replacement therapy.
Conclusion: There are differences in isoflavone intake of breast cancer
patients compared with healthy people and there was no difference in the status
of obese breast cancer patients compared to healthy individuals and isoflavone
intake less 2.85 times the risk of breast cancer compared with adequate intake
of isoflavones.
Keywords: risk factors;
isoflavon intake; breast cancer
Penulis: I Wayan Dwija Karyasa
Kode Jurnal: jpkesmasdd140742