Status gizi sebagai faktor prognosis penderita karsinoma endometrium
Abstract: In Indonesia,
endometrial cancer is the third gynaecologic cancer after cervical and ovarian
cancers. Various factors affect the survival of the patients, however, which
factors affect the survival of endometrial carcinoma patients in Dr. Sardjito
Hospital remain unclear. A research is therefore needed in order to determine
the survival and the prognostic factors.
Objective: To investigate the prognostic factors that affect the survival
of endometrial carcinoma patients who had been admitted to Dr. Sardjito
Hospital.
Method: The study design was retrospective cohort. The subjects were
patients with endometrial carcinoma who were treated in Dr. Sardjito Hospital
from 1st of January 2006 until 31st of December 2011. Kaplan-Meier analysis was
performed to analyze several factors that influenced the survival of the
patients. The differences of survival were analyzed with log rank test while
the prognostic factors influencing the survival were analyzed using Cox
regression.
Results: 68 endometrial carcinoma patients were recruited as the subjects
for the study. The median survival of endometrial carcinoma patients 52 months
for those on early stage and 17 months on advanced stage (p≤0.01). The
prognostic factors affecting survival that has been found statistically and
clinically significant was the stage of the disease (p=0.002; HR=6.175; 95%
CI=1.1980 to 19.25). Meanwhile, the nutritional status of patients with low,
normal, and high BMIs score showed increased survival rate as indicated by the
HR values of 1; 0.768; and 0.311 respectively.
Conclusion: The prognostic factor that was clinically and statistically
significant influenced the survival was the stage of the disease, while the
nutritional status of patients was found clinically significant as the prognostic
survival of the patients.
Keywords: endometrial
carcinoma; nutritional status; survival rate; prognostic factors; stage of
disease
Penulis: Heru Pradjatmo
Kode Jurnal: jpkesmasdd130682
