Efek Ekstrak Kulit Mangga Arumanis (Mangifera indica L.) terhadap Paw Licking Time Mencit Putih Jantan yang Diinduksi Formalin
ABSTRACT: Mango is one of the
plants which have a lot of benefits in pharmacology. Total phenol in its peel
is higher than in its flesh with the main component is mangiferin and quercetin
which known have activity to inhibit cyclooxygenase 2 (COX-2) enzyme. The
inhibition of COX-2 leads to the decrease of the production of prostaglandin
(PgE2) so it can reduce pain which marked by the decrease of paw licking time
on mice induced by formalin. Formalin-induced pain is divided into two phase:
early phase at 0-5th minutes and late phase at 15-30th minutes. The aim of this
research was to know the effect of Arumanis mango peel extract to decrease the
paw licking time in white male mice. The research design was true experimental.
The result of analyses used One Way Anova shows that there were significant
difference in each treatment groups with significance p < 0,05. The LSD
analysis on late phase showed no significant difference between the fifth
treatment group and the positive control group in LSD test. It can be concluded
that arumanis mango peel extract has equal effect with natrium diclofenac in decreasing
paw licking time on late phase in dosage 26 mg/g.
Keywords: mango peel, paw
licking time, flavonoid
Penulis: Rosita Sopwi Nur
Lailly, Cicih Komariah, Rosita Dewi
Kode Jurnal: jpkesmasdd160515
