Optimasi Suhu dan Lama Pemanasan dalam Pembentukan Kompleks Inklusi Glibenklamid-β-Siklodekstrin dengan Metode Sealed-Heating
ABSTRACT: Glibenclamide is a
second-generation sulfonylurea that used for type II diabetes mellitus.
Glibenclamide is included in the biopharmaceutical classification system (BCS)
class II, which has a low solubility and high permeability. One effort that can
be done to improve the solubility of drug is inclusion complexation. The aims
of the study was to determine temperature and heating time on inclusion
complexation of glibenclamide-β-cyclodextrin using sealed-heating method.
Optimization done using a factorial design for two factors with 22 number of
experiments. Inclusion complexes were determined its miosture content,
solubility and in vitro dissolution. Moisture content study showed that F1>
FB > FA > FAB. The results of solubility study were analyzed
statistically using One-Way ANOVA and least significantly different (LSD).
Statistical analysis showed that each formula had a significant difference
solubility with FAB > FB > FA > F1>Control. Optimization on in
vitro dissolution showed that FAB was an optimum formula with drug release of
87.24% within 180 min. This formula was characterized by DSC to observed for
broadening, shifting and appearance of new peaks or disappearance of certain
peaks. DSC analysis was indicated that inclusion complexation between
glibenclamide and β-cyclodextrin was formed.
Keywords: glibenclamide,
β-cyclodextrin, inclusion complexe, sealed-heating
Penulis: Aslyni Putri Suranina
Barus
Kode Jurnal: jpkesmasdd160510
