Pemberian kecambah kacang kedelai terhadap kadar malondialdehid (MDA) dan superoxide dismutase (SOD) tikus Sprague Dawley hiperkolesterolemia
Abstract: Consumption of foods
high in fat that happens in society can cause free radicals and trigger
oxidative stress that results in the accumulation of fat cells in the adipose,
cells damage and even cells death. An antioxidant activity that originates from
food in the body, depends on the number of substances that can be absorbed and
used to metabolism process. The selection of groceries that right can be
alternatives management in hyperlipidemia. Soybean sprouts have properties that
neutralize free radicals cause hyperlipidemia and cardiovascular diseases
because it is an antioxidant compound.
Objective: The aim of this study was to determine the effect of soybean
sprouts (Glycine Max) to levels of MDA and levels of SOD of male Sprague-Dawley
rats.
Method: Research laboratory tests design post only controlled group
design. The sample was 30 tailed rat Rattus norvegicus species Sprague Dawley.
The rat 8-10 weeks and samples to be divided into 5 group. Group 1 was normal
rat without treatment; groups II are hypercholesterolemic rat without
treatment; groups III are hypercholesterolemic rat with treatment sprouts
soybeans 0,53 g; group IV are hypercholesterolemic rat with treatment sprouts
soybeans 1,06 g; the group V are hypercholesterolemic rat with treatment
sprouts soybeans 2,12 g and all groups are treatment for 4 week.
Results: After four weeks of treatment, decline MDA levels in the
hypercholesterolemic rat. Doses the provision of sprouts soybean 2,12 g/day is
dosed most effective shown the significant differences (p<0.05) between the
treatment group first to the treatment third group. Statistical analysis to SOD
levels show differences meaningful in all the treatment group (p<0.05).
Doses the provision of sprouts soybean 2,12 g/day proven effective against
elevated levels of sod who demonstrated the significant differences (p=0,004)
between the treatment group 1 (X1) to the treatment group 3 (X3).
Conclusion: Doses sprouts 2,12 g is dosed optimal in preventing elevated
levels of MDA and help improve levels of SOD hypercholesterolemic
Sprague-Dawley rats.
Keywords: hypercholesterolemic;
levels of MDA; levels of SOD; soybean sprout
Penulis: Denny Indra Setiawan
Kode Jurnal: jpkesmasdd160590
