Pencegahan hipertensi dan penebalan dinding aorta dengan pemberian kecambah kacang hijau (Phaseolus radiatus (L)) pada tikus putih Sprague Dawley
Abstract: Lifestyle changes
with high-fat food consumption is one of the factors the risks of
cardiovascular diseases like of coronary heart disease and atherosclerosis. A
healthy diet and a balanced diet and consume foods that contain lots of
antioxidants is one of the effective ways to prevent hyperlipidemia. Mung bean
sprouts have properties that neutralize free radicals cause Hyperlipidemia and
cardiovascular diseases because it is an antioxidant compound.
Objective: The aim of this study was to determinate the effect of mung
bean sprouts (Phaseolus radiatus (L)) to blood pressure and histopathology
aorta of Sprague-Dawley male rats.
Method: The type of study was experimental research using pre-post test
controlled group design for blood pressure variable and post test only
controlled group design histopathology aorta. The thirty-five of Sprague-Dawley
male rats was eight weeks divided into 5 groups. The first group was given standard
diet, group 2 was given a hight fat diet, the third group was given a high-fat
diet and mung bean sprout 0,67 gram, group 4 was given a high-fat diet and mung
bean 1,34 gram, and group 5 was given a high-fat diet and vitamin E doses of 23
IU.
Results: Result of this study showed that after 4 weeks of treatment,
increased in blood pressure systole in the given of high fat diet higher than group who were
given a high fat diet and mung bean sprout and also on group who were given
high fat diet and vitamin E, but there is no difference effect a decrease in
blood pressure between the provision of mung bean sprouts and vitamin E
(p>0,05). Statistical analysis to thick the wall the aorta show the
similarity meaningful in all the treatment group, it can be said that overall
thick the wall the aorta in this research is not different.
Conclusion: A dose of mung bean sprout 0,67 g is optimal doses in
preventing a rise in blood pressure and prevent alterations histopathology
Sprague-Dawley male rats.
Keywords: blood pressure; high
fat diet; histopatology aorta; mung bean sprouts
Penulis: Novian Swasono Hadi, Arta
Farmawati, Ahmad Ghozali
Kode Jurnal: jpkesmasdd160582
