Pengaruh Gel Ekstrak dan Serbuk Mentimun (Cucumis sativus) terhadap Angiogenesis pada Penyembuhan Luka Bakar Derajat IIB pada Tikus Wistar
ABSTRACT: Burns is a serious
global health problem. Annually, 265.000 dead occured because of burns. Local
burns wound treatment ideally uses material that can act as antimicrobial and
antiinflamation, as well conditions moist environtment. Cucumber contains
flavonoid and saponin that enhance Vascular Endothelial Growth Factor that can
increase angiogenesis. The purpose of this research was to investigate the
effect of cucumber extract gel and cucumber powder gel on number of vascular
lumen angiogenesis of IIB-burn wound healing in wistar rat. This research was
true experimental laboratories with post test control only design by using
wistar rats and divided into 8 groups. Rats were burns-induced and then
terminated on the 3rd and the 10th day, each group consist of negative control
group (normal saline), positive control group (gentamycin eye ointment),
treatment group 1 (cucumber extract gel), treatment group 2 (cucumber powder
gel). Data analysis using One Way ANOVA test for the 3rd day and the 10th day
on vascular lumen number showed 0,031 and 0,036 (p<0,05) significance
respectively. In conclusion, there was significant difference for cucumber
extract gel and cucumber powder gel towards vascular lumen number in IIB-burns
wound healing in wistar rat.
Keywords: Burns, wound
healing, angiogenesis, cucumber (Cucumis sativus)
Penulis: Ardhina Mahadica
Nugroho
Kode Jurnal: jpkesmasdd160520
