Pengaruh jamur tiram putih (pleurotus ostreatus) terhadap kadar glukosa darah, profil lipid dan kadar MDA pada tikus (rattus norvegicus) diabetes melitus
Abstract: Diabetes mellitus is
a chronic disease caused by acquired deficiency in insulin production by the
pancreas, or by the ineffectiveness of using the produced insulin. Oyster
mushroom (Pleurotus ostreatus) can help lower blood glucose levels, improve
lipid profile and reduce levels of MDA.
Objective : to analyze the effect of oyster mushroom on blood glucose
levels, lipid profile and MDA levels in STZ induced rats as type 1 DM model.
Methods : thirty Sprague Dawley rats were randomly divided into 3 groups:
one positive group (1) and two treated group which received 100 mg/kgBB (2) and
200 mg/kgBB (3) oyster mushroom extract, respectively. The interventions were
carried out for 30 days. The examination of blood glucose levels, lipid profile
and MDA levels was before and after the intervention. The differences inthe
datapre-post interventions were analyzed by paired t-test, whereas the
differences between the groups were analyzed by one-way ANOVA and kruskal
wallis followed by post hoc analysis.
Results : the treatment group experienced a decrease in blood glucose
levels, total cholesterol, LDL cholesterol, triglycerides, MDA and an increase
in HDL cholesterol levels post-intervention (p < 0,001). Oyster mushroom
extract with the dose of 200 mg/kg was more effective in lowering blood glucose
levels, MDA levels and improving lipid profiles (p < 0,001).
Conclusion : Oyster mushrooms administration lowers blood glucose levels,
total cholesterol, LDL cholesterol, triglycerides, MDA and increases HDL
cholesterol levels.
Keywords: oyster mushroom
(Pleurotus ostreatus), blood glucose, lipid profile, Malondialdehyde, diabetes
Penulis: Purbowati, Andrew
Johan, RA Kisdjamiatun RMD
Kode Jurnal: jpkesmasdd160560
