Pengaruh kombinasi vitamin c dan vitamin e terhadap Kadar malondialdehid plasma pasien diabetes mellitus tipe 2
Abstract: Malondialdehyde
(MDA) levels produced by oxidative stress in type 2 diabetes mellitus (T2DM) is
higher than in non diabetes patients. Vitamin C and E inhibit oxidative stress
and MDA production. The purpose of this study was to prove the effects of
combined vitamin C and vitamin E on MDA plasma levels in T2DM patients.
Methods: This double blind randomized pre post test control group design
was carried out on 35 patients with T2DM without complication (age 40-60 yr) in
Makassar. The treatment group (n=18) received vitamin C 250 mg/day plus vitamin
E 400 IU/day and the control group (n=17) received placebo (seaweed powder 250
mg), for six weeks. Vitamin C was consumed before meal and vitamin E after
meal. MDA levels were measured before and after supplementation by using TBARs
method. Food intake and activity were derived from 24-hour recall method.
Results: There was no different on MDA levels at baseline (p=0.151). At
the end of the study, MDA levels increased in control group (5.8±2.74 to
7.2±3.00 nmol/ml; p=0.044) but not in the treatment group (7.2±2.88 to 7.7±2.02
nmol/ml; p=0.490). There was no difference in MDA alteration between the goups
(p=0.316). There was no different in MDA levels at the end of the study
(p=0.061) and confirmed after controlling the confounding variables: vitamin E
intake and fasting blood glucose (p=0.809).
Conclusion: Combined vitamin C 250
mg and vitamin E 400 IU for 6 weeks did not reduce MDA levels, but inhibit MDA
production in T2DM patients.
Keywords: Malondialdehid;
Vitamin C; Vitamin E; Diabetes Mellitus Tipe 2
Penulis: Yade Kurnia Yasin,
Martha Irene Kartasurya, RA Kisdjamiatun RMD
Kode Jurnal: jpkesmasdd150743
