Pengaruh Pemberian Ekstrak Propolis Terhadap Kadar Kolesterol Darah Tikus Wistar Jantan Setelah Dipapar Sidestream Cigarette Smoke
ABSTRACT: Smoking is one of
environment factors which caused a bad effect for health. TheSidestream
Cigarette Smoke (SCS) contained in smoke produce free radicals highly andincrease
total cholesterol levels. Elevated levels of total cholesterol can be treated
withmedicine of statins, but its use in the long term cause side effects.
Therefore, at thistime medicine has been developed from natural a substance
which is expected have less side effects, one of which is propolis. This
research aims to determine whether thereis a decrease in total cholesterol
levels in male Wistar rats (Rattus norvegicus) whichwas given extracts of
propolis and exposed SCS. The research is experimentallaboratory with post test
control group design. This research uses 12 rats which consist of 2 groups (1
control and 2 groups of treatment). The first treatment group is exposedby SCS.
The second one is exposed by SCS and given the extract of propolis 2 times aday
for 8 days. The total blood cholesterol level is measured by using spectrophotometer
with enzymatic colorimetric methods. The results of data analysis using One Way
Anova test shows there is a significant difference in total bloodcholesterol
level means of male Wistar rats (p <0.05). While the Tukey HSD test showsthere
is a significant difference in total cholesterol level means between groups,
exceptbetween the control group and the second treatment group. Conclusion of
this research is that the propolis extract can lower total cholesterol levels
of male Wistar ratswhich given exposure of Sidestream Cigarette Smoke.
Keywords: blood cholesterol
levels, propolis extract, sidestream cigarette smoke
Penulis: Chusna Sekar Wardani
Kode Jurnal: jpkesmasdd160526
