Pengaruh Pemberian Gel Doksisiklin terhadap Jumlah Makrofag pada Proses Penyembuhan Dermatitis Paederus akibat Racun Tomcat (Paederus sp.) pada Mencit
ABSTRACT: Paederus dermatitis
is an acute skin irritation caused by skin contact with toxins in the rove
beetle (Paederus sp). Pederin poison was previously thought derived from the
rove beetle's body. Based on other studies, poison pederin obtain from the
symbiotic rove beetles and Pseudomonas aeruginosa which is able to secrete the
matrix metalloprotease (MMP). Doxycycline is an antibiotic act as an inhibitor
of MMP. This study aimed to verify the effect of Doxycycline gel to the number
of macrophages in healing process Paederus dermatitis due to poison of rove
beetle (Paederus sp.). The study design was a quasy experimental design using
40 mice (Mus musculus), were divided into 4 groups. Normal control group,
negative control group, P1 group was given doxycycline 1%, and P2 group was
given doxycycline 5%. Experimental animals were terminated on day 1, 3, 5, 7,
and 15. The result of One Way Annova test on the number of macrophages on day
1, 3 and 5 showed a significance of 0.00 (p<0.05). This study showed that there
was a significant difference in the effect of doxycycline gel to the number of
macrophages in healing process of Paederus dermatitis.
Keywords: dermatitis paederus,
doxycycline gel, macrophages
Penulis: Bagus Indra Kusuma, Al
Munawir, Septa Surya Wahyudi
Kode Jurnal: jpkesmasdd160509
