PENGARUH PEMBERIAN Zn TERHADAP KADAR GLUKOSA DARAH DAN KADAR SUPEROKSIDA DISMUTASE PADA TIKUS WISTAR YANG DIINDUKSI STREPTOZOTOCIN
Abstract: Diabetes mellitus is
a metabolic disease characterized by hyperglycemia. Giving Zn could reduce the
reactivity of ROS due tohyperglycemia by increasing SOD status. Zinc ability as
an antioxidant alsocan improve blood glucose level in diabetes mellitus
patients. To prove the effect of Zn with the doses of 3 mg/kg BW and 5 mg/kg BW
for 30 days onblood glucose and SOD levels in Wistar rats induced by STZ.
Twenty-eight rats were divided into 4 groups includes K1 as a negative control
group, K2 as a positive control group that is induced by STZ 40 mg/kg BW, K3 as
a group that is induced by STZ 40 mg/kg BW and Zn were given at a dose of 3
mg/kg BW for 30 days orally and K4 as aa group that is induced by STZ40 mg/kg
BW and Zn were given at a dose of 5 mg/kg BW for 30 days orally. Examination of
blood glucose levels used GODPAP methods and SOD levelschecked with a
colorimeter method. Data were analyzed using Paired T-Tests and Wilcoxon tests.
There was a signifcant decrease in blood glucose levels after administration of
3 mg/kg BW Zn (p = 0,003) and 5 mg/kg BW (p = 0.018) for 30 days in Wistar rats
induced by STZ. There was no signifcantincrease in SOD levels after
administration of 3 mg/kg BW Zn (p = 0,120) but a signifcant increase in SOD
levels after administration of 5 mg/kg BW Zn(p = 0,038) for 30 days in Wistar
rats induced by STZ. Administration of 5 mg/kg BW Zn for 30 days showed a
better effect on blood glucose and SODlevels in Wistar rats induced by STZ when
compared with administration of3 mg/kg BW Zn.
Keywords: Zn, blood glucose,
superoxide dismutase, diabetes
Penulis: Nadini Kartika,
Banundari Rachmawati, Andrew Johan
Kode Jurnal: jpkesmasdd160497
