Pengaruh suplementasi seng dan vitamin B6 terhadap kadar hemoglobin, hematokrit dan indeks eritrosit pasien malaria vivax yang anemia
Abstract: Zinc supplementation
decrease the risk of malaria parasitaemia, increasing ferritin serum level and
hemoglobin in patients with malaria. Zinc influence the activity of
aminolevulinic acid dehydratase (ALAD) an enzymes that catalizes heme synthesize.
Vitamin B6 in pyridoxal 5-phosphate (PLP) from has a role in
alpha-aminolevulinic acid (ALA) formation, which is the precursor of heme in
hemoglobin. PLP also inhibit the growth of the malaria parasite.
Objective: The objective was to analyze the effect of zinc and vitamin B6
supplementation on hemoglobin level, hematocrit and erythrocyte indexs (MCV,
MCH and MCHC) of anemic Plasmodium vivax malaria patients.
Methods: Double Blind Randomised Controlled Trial with pre and post test
design. 30 subjects were divided into two groups: the suplementation group were
given zinc 1x10 mg/day with vitamin B6 1x5 mg/day and the control group were
given a placebo for 30 days. Data analysis by paired t-test, independent t-test
and Mann Whitney.
Results: There was an increase in Hb levels in the suplementation group
(p=0.0001), the control group (p=0.001) and there was a significant difference
on the increase between the two groups (p=0.020). Hematocrit significant
increase only in the suplementation group (p=0.0001). There were no differences
on erythrocyte index parameter in both groups.
Conclusion: Zinc and vitamin B6 supplementation of for 30 days increase
the hemoglobin level, hematocrit and there were no effect on erythrocyte indexs
of anemic Plasmodium vivax malaria patients.
Keywords: Zinc, vitamin B6,
malaria vivax, haemoglobin, hematocrit and erythrocyte index
Penulis: Sofiyetti, Edi
Dharmana, M. Zen Rahfiludin, Nyoman Suci W, Diana Nur Afifah
Kode Jurnal: jpkesmasdd160565
