Potensi glukomanan pada tepung porang sebagai agen anti-obesitas pada tikus dengan induksi diet tinggi lemak
Abstract: Epidemiological
studies indicate that the global prevalence of obesity has increased.
Glucomannan is a water-soluble, non-starch polysaccharide, known as soluble
fiber. Glucomannan has the ability to lower blood cholesterol levels and blood
glucose levels, weight loss and affects the activity of intestinal and immune
system function.
Objective: The purpose of this study was to determine the effect of
glucomannan derived from konjac flour as antiobesity agent on body weight and
food intake in rats induced by high-fat diet.
Method: Research was conducted in the Pharmacology Laboratory, Faculty of
Medicine, University of Brawijaya. This study uses a true experimental research
design. Animals were divided into six groups, normal group, normal + konjac
flour, obese group, obese group + konjac flour 100 mg/kg body weight, obese
group + konjac flour 200 mg/kg body weight, obese group + konjac flour 400
mg/kg.
Results: Based on One-way ANOVA test, there is a significant difference
(p: 0.000) on body weight after konjac flour treatment in all groups. Based on
the Kruskal-Wallis test, there is a difference in food intake in various groups
(p = 0.000).
Conclusion: It can be concluded that glucomannan derived from konjac
flour can decrease body weight and food intake in rats induced by high-fat
diet.
Keywords: body weight; food
intake; glucomannan; konjac flour; obesity
Penulis: Choirun Nissa
Kode Jurnal: jpkesmasdd160588
