Antipsychotic Use Evaluation on First Episode Schizophrenic Patients at Jambi Psychiatric Hospital
Abstract: Patients with first
episode schizophrenia need relatively lower effective antipsychotic doses, had
higher sensitivity toward side effects and symptoms free response were easier
to achieve compared to multi episode schizophrenic patients. This episode is the
critical stage that will affect further development of the disease.
Antipsychotic use evaluation was needed to achieve an optimal therapy for first
episode schizophrenic patients. Study was conducted using retrospective method.
The data were taken from medical records, nurse monitoring forms and
consultation with health care professionals. The study showed that the most
prescribed antipsychotic was the combination of chlorpromazine and haloperidol
(37.12%), risperidone was the most prescribed antipsychotic as single therapy
(35.71%) and there were 34.29% therapeutic regiments that higher than
recommended dose. The most prescribed drug that added to the antipsychotic
therapy was trihexyphenidyl (69.29%). There were 97 drug interaction cases with
six pharmacokinetic interaction cases which dosage adjustment was needed. There
were seven patients (17.07%) that had continued therapy until 10 months and
four cases of relapse ought to alcohol consumption (one case) and therapeutic
non adherence (three cases). The pharmacotherapy guideline for first episode
schizophrenia patients in Jambi Psychiatric Hospital is needed to be revised
ought to some differences between prescribed antipsychotic and recommended
guidelines.
Keywords: Drug Use Evaluation,
Antipsychotic, First-Episode Schizophrenia
Penulis: Rifani Bhakti Natari,
Elin Yulinah Sukandar, Joseph Iskendiarso Sigit
Kode Jurnal: jpfarmasidd120339
