Efek Analgesik Kombinasi Kurkumin dan Parasetamol pada Mencit yang Diinduksi Asam Asetat menggunakan Isobologram
ABSTRACT: Paracetamol is a
drug that classified as NSAID and commonly used as analgesic agent. These drugs
have toxic effects that lead to liver damage. This effects caused by
accumulation the metabolite compound of paracetamol, N-acetyl-p-benzoquinone
(NAPQI), by cytochrome P450 enzyme. Some studies reported that curcumin have
analgesic effects and inhibit action of cytochrome P450 enzyme. The purpose of
this study was to determine the analgesic effect of curcumin and paracetamol
combination in 27 acetic-acid induced mice. The result of this study showed
that 2358,815 µg of curcumin and paracetamol combination can inhibit pain up to
50%. This result is smaller than paracetamol that need 4200 µg to achieve the
same pain inhibition. One Way Annova test showed siginificant difference
between paracetamol group and combination group. Isobolographic analysis
results showed curcumin and paracetamol have synergistic properties in mice
acetic-acid induced pain.
Keywords: curcumin, paracetamol,
isobolograph
Penulis: Nugroho Priyo Utomo, Cicih
Komariah, Yudha Nurdian, Yudha Nurdian
Kode Jurnal: jpkesmasdd170069
