Efek Ekstrak Kulit Mangga (Mangifera indica L.) Arumanis terhadap Lama Perdarahan Mencit Putih Jantan
ABSTRACT: The inhibition of
cyclooxygenase 1 (COX-1) enzyme leads to the decrease of tromboxane A2 (TXA2)
and decrease the activity of platelet aggregation that marked by the
lengthening of bleeding time. This mechanism is important to prevent the
occurence of patology that can lead to thrombosis. Flavonoid, polyphenol
present in the mango peel, is known to have activity for blocking the COX-1
enzyme. The aim of this research was to know the effect of Arumanis mango peel
extract for lengthening the bleeding time on white male mice. The research was
true experimental. The sampel was treated for seven days and the bleeding time
was measured on the seventh day. The result of analyses Kruskal Wallis shows
that there are significant difference intern-treatment group with significance
(p) 0.033. The Mann Whitney analyses test shows significant difference between
treatment group 2 (P2), treatment group 4 (P4), treatment group 5 (P5) and
negative control group (K-). So, it can be concluded that arumanis mango peel
extract can lengthening the bleeding time of white male mice.The dosis of 16,8
mg.grBBof mango peel extract givesthe longest mean bleeding timeand it exceeds
the mean of positive control group.
Keywords: bleeding time,
mango, flavonoid
Penulis: Komang Dewi
Fridayanti, Cicih Komariah, Jauhar Firdaus
Kode Jurnal: jpkesmasdd170032
